{Reference Type}: Journal Article
{Title}: The Immunophenotypic Profile of Healthy Human Bone Marrow.
{Author}: Lewis JE;Hergott CB;
{Journal}: Clin Lab Med
{Volume}: 43
{Issue}: 3
{Year}: 2023 09
{Factor}: 2.172
{DOI}: 10.1016/j.cll.2023.04.003
{Abstract}: Flow cytometry enables multiparametric characterization of hematopoietic cell immunophenotype. Deviations from normal immunophenotypic patterns comprise a cardinal feature of many hematopoietic neoplasms, underscoring the ongoing essentiality of flow cytometry as a diagnostic tool. However, understanding of aberrant hematopoiesis requires an equal understanding of normal hematopoiesis as a comparator. In this review, we outline key features of healthy adult hematopoiesis and lineage specification as illuminated by flow cytometry and provide diagrams illustrating what a diagnostician may observe in flow cytometric plots. These features provide a profile of baseline hematopoiesis, to which clinical samples with suspected neoplasia may be compared.