{Reference Type}: Review
{Title}: Keratin-Positive Giant Cell-Rich Tumor of Bone Harboring an HMGA2::NCOR2 Fusion: Two Cases, Including a Patient With Metastatic Disease, and Review of the Literature.
{Author}: Patton A;Ilaslan H;Armstrong SM;Bakhshwin A;Cheng YW;Minhas F;Fritchie KJ;
{Journal}: Int J Surg Pathol
{Volume}: 32
{Issue}: 3
{Year}: 2024 May 17
{Factor}: 1.358
{DOI}: 10.1177/10668969231185076
{Abstract}: Giant cell-rich lesions of bone represent a heterogeneous group of entities which classically include giant cell tumor of bone, aneurysmal bone cyst, nonossifying fibroma, and Brown tumor of hyperparathyroidism. A recently described subset of giant cell-rich tumors involving bone and soft tissue has been characterized by recurrent HMGA2::NCOR2 fusions and keratin expression. The overlapping clinical, radiographic, and morphological features of these giant cell-rich lesions provide a unique diagnostic challenge, particularly on biopsy. We present 2 additional cases of keratin-positive giant cell-rich tumor of bone with HMGA2::NCOR2 fusions, including 1 patient who developed metastatic disease.