{Reference Type}: Case Reports
{Title}: Successful use of Rectal Pregabalin for the Treatment of Chemotherapy-Induced Neuropathic Pain-a Case Report.
{Author}: Roch C;Para S;Brandhofer C;Seitz AK;Rémi C;Berner J;van Oorschot B;
{Journal}: J Palliat Care
{Volume}: 38
{Issue}: 4
{Year}: 2023 Oct 16
{Factor}: 1.98
{DOI}: 10.1177/08258597231189151
{Abstract}: <B>BACKGROUND: </B>A 65-year-old female patient could no longer take oral food or medications due to a duodenal occlusion associated with metastatic urothelial carcinoma. Her pre-existing chemotherapy-induced polyneuropathy had been well treated with pregabalin orally.<BR><B>METHODS: </B>Since only preparations for oral use of pregabalin are available, pregabalin suppositories were compounded by the hospital pharmacy for rectal use in this patient.<BR><B>RESULTS: </B>With the rectal administration, the treatment was successfully continued; we measured a good increase in serum levels and the symptoms improved significantly.<BR><B>CONCLUSIONS: </B>Cancer patients often need to be treated with co-analgesics. At the end of life, treatment often cannot be continued due to lack of other than oral administration. Our case adds to the low evidence of pregabalin administered rectally.