{Reference Type}: Review
{Title}: Bone metastases with "false negative" findings on 18F-FDG PET/CT in patients with angiosarcoma: A case series with literature review.
{Author}: Ariga A;Matsumoto S;Tanizawa T;Hayakawa K;Minami Y;Saito M;Kurosawa N;Yamashita K;Terauchi T;Ae K;
{Journal}: Medicine (Baltimore)
{Volume}: 102
{Issue}: 28
{Year}: 2023 Jul 14
{Factor}: 1.817
{DOI}: 10.1097/MD.0000000000034196
{Abstract}: <B>BACKGROUND: </B>Fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) is considered a reliable and indispensable imaging method when evaluating distant metastases and clinical staging of angiosarcomas. Here, we report 2 cases of angiosarcoma with bone metastases with "false negative" findings on 18F-FDG PET/CT.<BR><B>METHODS: </B>Case 1, a 39-year-old woman, who had undergone mastectomy for primary angiosarcoma 2 years prior, presented with a 5-month history of right coxalgia. Case 2 was a 37-year-old woman, who had undergone mastectomy for primary angiosarcoma 4 months prior. During postoperative follow-up, multiple bone lesions were detected on magnetic resonance imaging (MRI).<BR><B>METHODS: </B>Based on the histopathological findings, both cases were diagnosed with bone metastases of angiosarcoma. Although MRI showed multiple bone metastatic lesions, 18F-FDG PET/CT showed no uptake or osteolytic destruction in both cases.<BR><B>METHODS: </B>Weekly paclitaxel was initiated as a salvage chemotherapy in both cases.<BR><B>RESULTS: </B>No uptake or osteolytic lesions were observed on 18F-FDG PET/CT, despite multiple bone metastases detected on MRI.<BR><B>CONCLUSIONS: </B>False-negative findings on 18F-FDG PET/CT should be considered when evaluating bone metastases of angiosarcoma. Even with negative findings on 18F-FDG PET/CT, open biopsy should be performed if MRI indicates bone metastases.