{Reference Type}: Review {Title}: Primary Retinal Cell Cultures as a Model to Study Retina Biology. {Author}: Michelis GA;Politi LE;Becerra SP; {Journal}: Adv Exp Med Biol {Volume}: 1415 {Issue}: 0 {Year}: 2023 {Factor}: 3.65 {DOI}: 10.1007/978-3-031-27681-1_82 {Abstract}: Since its inception, primary retinal cultures have been an in vitro tool for modeling the in vivo environment of the retina for biological studies on development and disease. They offer simple and controlled experimental approaches when compared to in vivo models. In this review we highlight the strengths and weaknesses of primary retinal culture models, and the features of dispersed retinal cell cultures.