{Reference Type}: Case Reports {Title}: Pylephlebitis Caused by Bacillus subtilis and Fusobacterium nucleatum. {Author}: Ochi T;Oh K;Konishi H; {Journal}: Intern Med {Volume}: 63 {Issue}: 6 {Year}: 2024 Mar 15 {Factor}: 1.282 {DOI}: 10.2169/internalmedicine.2150-23 {Abstract}: A 90-year-old man presented with a 3-day history of general malaise. He was febrile (39.3°C) but the initial evaluation did not reveal the cause of the fever. After admission, Bacillus subtilis and Fusobacterium nucleatum were grown from multiple sets of blood cultures. In addition, contrast-enhanced computed tomography revealed thrombi in the portal vein and superior mesenteric vein; he was diagnosed with pylephlebitis. After receiving antimicrobial treatment and anticoagulation, the patient was cured. Pylephlebitis is a rare condition and may be the cause of unknown fevers. This is the first reported case of pylephlebitis caused by Bacillus subtilis.