{Reference Type}: Journal Article
{Title}: The DEAD-box RNA helicase Dbp5 is a key protein that couples multiple steps in gene expression.
{Author}: Querl L;Krebber H;
{Journal}: Biol Chem
{Volume}: 404
{Issue}: 8
{Year}: 2023 07 26
{Factor}: 4.7
{DOI}: 10.1515/hsz-2023-0130
{Abstract}: Cell viability largely depends on the surveillance of mRNA export and translation. Upon pre-mRNA processing and nuclear quality control, mature mRNAs are exported into the cytoplasm via Mex67-Mtr2 attachment. At the cytoplasmic site of the nuclear pore complex, the export receptor is displaced by the action of the DEAD-box RNA helicase Dbp5. Subsequent quality control of the open reading frame requires translation. Our studies suggest an involvement of Dbp5 in cytoplasmic no-go-and non-stop decay. Most importantly, we have also identified a key function for Dbp5 in translation termination, which identifies this helicase as a master regulator of mRNA expression.