{Reference Type}: Review
{Title}: Secretory breast cancer in a boy: A case report with genetic analysis using next-generation sequencing and literature review.
{Author}: Deng L;Li Y;Zhong J;
{Journal}: Medicine (Baltimore)
{Volume}: 102
{Issue}: 27
{Year}: 2023 Jul 7
{Factor}: 1.817
{DOI}: 10.1097/MD.0000000000034192
{Abstract}: <B>BACKGROUND: </B>Male secretory breast cancer is a rare, low-grade carcinoma, especially in boys. Due to its rarity, not much is known about this disease.<BR><B>METHODS: </B>A 5-year-old boy presented with a 1.4 cm painless mass in the right breast.<BR><B>METHODS: </B>Ultrasonography could not distinguish whether the breast tumor was benign or malignant. After a biopsy of the lumpectomy specimen, it was diagnosed to be secretory breast carcinoma.<BR><B>METHODS: </B>The patient underwent a modified radical mastectomy for his right breast. No postoperative chemotherapy or radiotherapy was performed. Next-generation sequencing of 211 cancer-related genes was detected, and the results revealed an ETV6-NTRK3 translocation and a PDGFRB c.2632A > G mutation. None of the most commonly altered molecules in male aggressive breast cancer (such as BRCA1-2, TP53, RAD51C, and RAD51D mutations) has been identified.<BR><B>RESULTS: </B>The patient was still free from local recurrence or metastases at 6-month follow-up.<BR><B>CONCLUSIONS: </B>The genomic profile of male pediatric SCB is relatively simple, no other known driver genes have been found except for the ETV6-NTRK3 fusion. Our report will improve our understanding of secretory breast cancer.