{Reference Type}: Review
{Title}: Evaluation of tumour size and rete testis invasion in progression free survival of our patients with stage i testicular seminoma. A retrospective observational study of a reference hospital center and literature review.
{Author}: Yáñez-Castillo YM;Melgarejo-Segura MT;Gutiérrez-Tejero F;Arrabal-Martín M;
{Journal}: Actas Urol Esp (Engl Ed)
{Volume}: 47
{Issue}: 10
{Year}: 2023 Dec 22
暂无{DOI}: 10.1016/j.acuroe.2023.06.005
{Abstract}: <B>BACKGROUND: </B>The aim of this study was to evaluate the impact of tumour size and rete testis invasion in progression free survival of our patients with stage I testicular seminoma. A literature review is also made.<BR><B>METHODS: </B>A retrospective observational study was performed. We included patients with stage I seminoma between January 2010 and July 2022. Patients without factors of poor prognostic -Group A- were compared with patients with factors of poor prognostic -Group B-. Kaplan-Meier curves and log-rank testing were used to compare progression free survival (PFS) between these groups. Statistical significance was considered at P≤.05.<BR><B>RESULTS: </B>55 patients were included in this study. 20 patients (36.4%) were of good prognostic -Group A- and 35 (63.6%) had factors of poor prognostic -Group B-. The mean age was similar in both groups (mean±standard deviation), 38.62±9.04 years. The mean follow-up time was 63.5±33.6 months. All the patients in group A and 25.7% of the patients in group B underwent active surveillance (AS). 26 patients (74.3%) of the patients in Group B were treated with one cycle of adyuvant carboplatin. Three patients suffered a relapse with retroperitoneal lymph nodes (10.3%), all of them were treated with three cycles of BEP, with a complete response of the disease. No statistical significant differences were found in PFS between Group A and B (log Rank P=.317).<BR><B>CONCLUSIONS: </B>Individualization of adjuvant treatment in stage I seminoma is important, avoiding the adverse effects derived from them.