{Reference Type}: Case Reports
{Title}: Case report: Regression of Glioblastoma after flavivirus infection.
{Author}: Garcez PP;Guasti A;Ventura N;Higa LM;Andreiuolo F;de Freitas GPA;Ribeiro LJ;Maia RA;de Lima SMB;de Souza Azevedo A;Schwarcz WD;Caride EC;Chimelli L;Dubois LG;Ferreira Júnior ODC;Tanuri A;Moura-Neto V;Niemeyer P;
{Journal}: Front Med (Lausanne)
{Volume}: 10
{Issue}: 0
{Year}: 2023
{Factor}: 5.058
{DOI}: 10.3389/fmed.2023.1192070
{Abstract}: Glioblastoma is the most frequent and aggressive primary brain cancer. In preclinical studies, Zika virus, a flavivirus that triggers the death of glioblastoma stem-like cells. However, the flavivirus oncolytic activity has not been demonstrated in human patients. Here we report a glioblastoma patient who received the standard of care therapy, including surgical resection, radiotherapy and temozolomide. However, shortly after the tumor mass resection, the patient was clinically diagnosed with a typical arbovirus-like infection, during a Zika virus outbreak in Brazil. Following the infection resolution, the glioblastoma regressed, and no recurrence was observed. This clinical response continues 6 years after the glioblastoma initial diagnosis.