{Reference Type}: Case Reports
{Title}: Repetitive Suicidal Behaviors in a Case With a New Mutation of Wolfram Syndrome: A Jump From the Gene to the Behavior.
{Author}: Mirfazeli FS;Mohebi F;Jahanbakhshi A;Aryani O;Almasi-Dooghaee M;
{Journal}: Basic Clin Neurosci
{Volume}: 13
{Issue}: 6
{Year}: 2022 Nov-Dec
暂无{DOI}: 10.32598/bcn.2021.910.3
{Abstract}: Wolfram syndrome (WS) is a rare autosomal recessive neurodegenerative disease with variable symptoms, including neuropsychiatric manifestations. A 26-year-old man was reported with classic symptoms of WS and repetitive psychiatric hospitalizations and at least 16 suicidal attempts. The genetic study demonstrated a novel homozygous stop-codon mutation on the WFS1 gene. This special type of mutation may be related to repetitive suicidal behaviors in this case of WS. Psychological support should be a routine practice in patients with WS.