{Reference Type}: Case Reports {Title}: Guided Zygomatic Implantology for Oral Cancer Rehabilitation: A Case Report. {Author}: Grecchi F;D'Ambrogio RG;Stefanelli LV;Grivetto F;Goker F;Del Fabbro M;Schreiber A;Piazza C;Salgarello S;Dosio C;Grecchi E; {Journal}: J Clin Med {Volume}: 12 {Issue}: 11 {Year}: 2023 May 24 {Factor}: 4.964 {DOI}: 10.3390/jcm12113653 {Abstract}: Oral rehabilitation after maxillary oncological resection is challenging. This case report presents the rehabilitation of a 65-year-old Caucasian male adenoid cystic carcinoma patient using a myo-cutaneous thigh flap, zygomatic implant placement, and an immediate fixed provisional prosthesis made with computer-aided technologies. The patient presented complaints of asymptomatic enlarged swelling of 5-mm on the right hard hemi-palate. There was an oro-antral communication deriving from a previous local excision. Preoperative radiographs showed the involvement of the right maxilla, maxillary sinus, and nose with a suspect involvement of the maxillary division of the trigeminal nerve. Treatment was planned through a fully digital workflow. A partial maxillectomy was performed endoscopically, and maxilla was reconstructed using an anterolateral thigh free flap. Two zygomatic implants were inserted simultaneously. A provisional fix full-arch prosthesis was manufactured preoperatively through a fully digital workflow and was placed in the operating room. Following post-operative radiotherapy, the patient received a final hybrid prosthesis. During the follow-up period of two years, the patient reported good function, aesthetics, and significant enhancement in quality of life. According to the results of this case, the protocol represented can be a promising alternative for oral cancer patients with large defects, and can lead to an improved quality of life.