{Reference Type}: Systematic Review
{Title}: Endemic Systemic Mycoses in Italy: A Systematic Review of Literature and a Practical Update.
{Author}: Zerbato V;Di Bella S;Pol R;D'Aleo F;Angheben A;Farina C;Conte M;Luzzaro F; ;Luzzati R;Principe L;
{Journal}: Mycopathologia
{Volume}: 188
{Issue}: 4
{Year}: 2023 Aug 9
{Factor}: 3.785
{DOI}: 10.1007/s11046-023-00735-z
{Abstract}: Endemic systemic mycoses such as blastomycosis, coccidioidomycosis, histoplasmosis, talaromycosis, paracoccidioidomycosis are emerging as an important cause of morbidity and mortality worldwide. We conducted a systematic review on endemic systemic mycoses reported in Italy from 1914 to nowadays. We found out: 105 cases of histoplasmosis, 15 of paracoccidioidomycosis, 10 of coccidioidomycosis, 10 of blastomycosis and 3 of talaromycosis. Most cases have been reported in returning travelers and expatriates or immigrants. Thirtytwo patients did not have a story of traveling to an endemic area. Fortysix subjects had HIV/AIDS. Immunosuppression was the major risk factor for getting these infections and for severe outcomes. We provided an overview on microbiological characteristics and clinical management principles of systemic endemic mycoses with a focus on the cases reported in Italy.