{Reference Type}: Meta-Analysis
{Title}: Comparative efficacy of therapies for relapsing multiple sclerosis: a systematic review and network meta-analysis.
{Author}: Samjoo IA;Drudge C;Walsh S;Tiwari S;Brennan R;Boer I;Häring DA;Klotz L;Adlard N;Banhazi J;
{Journal}: J Comp Eff Res
{Volume}: 12
{Issue}: 7
{Year}: 2023 07 2
{Factor}: 2.04
{DOI}: 10.57264/cer-2023-0016
{Abstract}: Aim: To assess the relative efficacy of disease-modifying therapies (DMTs) for relapsing multiple sclerosis (RMS) including newer therapies (ozanimod, ponesimod, ublituximab) using network meta-analysis (NMA). Materials & methods: Bayesian NMAs for annualised relapse rate (ARR) and time to 3-month and 6-month confirmed disability progression (3mCDP and 6mCDP) were conducted. Results: For each outcome, the three most efficacious treatments versus placebo were monoclonal antibody (mAb) therapies: alemtuzumab, ofatumumab, and ublituximab for ARR; alemtuzumab, ocrelizumab, and ofatumumab for 3mCDP; and alemtuzumab, natalizumab, and either ocrelizumab or ofatumumab (depending on the CDP definition used for included ofatumumab trials) for 6mCDP. Conclusion: The most efficacious DMTs for RMS were mAb therapies. Of the newer therapies, only ublituximab ranked among the three most efficacious treatments (for ARR).