{Reference Type}: Journal Article
{Title}: N/C-degron pathways and inhibitor development for PROTAC applications.
{Author}: Wu Z;Huang Y;Liu K;Min J;
{Journal}: Biochim Biophys Acta Gene Regul Mech
{Volume}: 1867
{Issue}: 1
{Year}: 2024 Mar 30
{Factor}: 6.304
{DOI}: 10.1016/j.bbagrm.2023.194952
{Abstract}: Ubiquitination is a fascinating post-translational modification that has received continuous attention since its discovery. In this review, we first provide a concise overview of the E3 ubiquitin ligases, delving into classification, characteristics and mechanisms of ubiquitination. We then specifically examine the ubiquitination pathways mediated by the N/C-degrons, discussing their unique features and substrate recognition mechanisms. Finally, we offer insights into the current state of development pertaining to inhibitors that target the N/C-degron pathways, as well as the promising advances in the field of PROTAC (PROteolysis TArgeting Chimeras). Overall, this review offers a comprehensive understanding of the rapidly-evolving field of ubiquitin biology.