{Reference Type}: Case Reports
{Title}: Anti-ganglioside antibody positive neuromyelitis optica spectrum disorders with peripheral neuropathy: a case report.
{Author}: Li Y;Tang M;Yu L;He Y;Liang L;Qu H;Si W;Hu X;
{Journal}: BMC Neurol
{Volume}: 23
{Issue}: 1
{Year}: 2023 May 12
{Factor}: 2.903
{DOI}: 10.1186/s12883-023-03214-6
{Abstract}: <B>BACKGROUND: </B>Neuromyelitis optica spectrum disorders (NMOSD) is a group of autoimmune-mediated disorders of the central nervous system primarily involving the optic nerve and spinal cord. There are limited reports of NMOSD associated with peripheral nerve damage.<BR><B>METHODS: </B>We report a 57-year-old female patient who met the diagnostic criteria for aquaporin 4 (AQP4)-IgG positive NMOSD with undifferentiated connective tissue disease and multiple peripheral neuropathy. In addition, the patient was positive for multiple anti-ganglioside antibodies (anti-GD1a IgG antibodies and anti-GD3 IgM antibodies) and anti-sulfatide IgG antibodies in serum and cerebrospinal fluid. After treatment with methylprednisolone, gamma globulin, plasma exchange, and rituximab, the patient's status improved and was subsequently discharged from our hospital.<BR><B>CONCLUSIONS: </B>The neurologist should be aware of the unusual association between NMOSD and immune-mediated peripheral neuropathy undifferentiated connective tissue disease and nerve damage mediated by multiple antibodies may have combined to cause peripheral nerve damage in this patient.