{Reference Type}: Journal Article
{Title}: In Vitro Study of Cytostatic Activity of Baicalin, Baicalein, and Chlorophyllipt on HeLa-v Cell Line.
{Author}: Boyko NN;Novikov OO;Zhilyakova ET;Pisarev DI;Nadezhdin SV;Zubareva EV;Lysenko AS;Lapshina EG;Yagnikov SA;Nikitchenko DV;
{Journal}: Bull Exp Biol Med
{Volume}: 174
{Issue}: 6
{Year}: 2023 Apr 12
{Factor}: 0.737
{DOI}: 10.1007/s10517-023-05782-6
{Abstract}: Cytostatic activity of baicalin, baicalein, and neogalenical drug Chlorophyllipt was studied in vitro on HeLa-v cells. Standard samples of Eucalimin, baicalin, and baicalein, as well as Chlorophyllipt and paclitaxel (reference drug Taxacad) were used. The cell deaths were determined by MTT assay in a Multiskan FC microplate reader with incubator. The effective inhibition concentration (IC50) of the tested substances were: paclitaxel (4.0±0.4 μM)-baicalein (10.5±1.1 μM)-baicalin (16.5±1.7 μM)-sum of euglobals in Chlorophyllipt (24.1±2.5 μM). Chlorophyllipt was found to exhibit cytostatic activity. Cytostatic activity of baicalein, baicalin, and Chlorophyllipt was lower than cytostatic activity of the reference drug by 2.6, 4.1, and 6 times, respectively. The prospects of further evaluation of the synergetic effect of baicalin, baicalein, and chlorophyllipt used in combinations with different cytostatic agents for finding the most effective combination have been shown.