{Reference Type}: Journal Article
{Title}: Exosomes Derived from Endothelial Cells Inhibit Neointimal Hyperplasia Induced by Carotid Artery Injury in Rats via ROS-NLRP3 Inflammasome Pathway.
{Author}: Yang SY;Deng WW;Zhao RZ;Long XP;Wang DM;Guo HH;Jiang LX;Chen WM;Shi B;
{Journal}: Bull Exp Biol Med
{Volume}: 174
{Issue}: 6
{Year}: 2023 Apr 10
{Factor}: 0.737
{DOI}: 10.1007/s10517-023-05788-0
{Abstract}: This study attempted to investigate whether exosomes derived from rat endothelial cells (EC-Exo) attenuate intimal hyperplasia after balloon injury using hematoxylin and eosin staining, immunohistochemistry, immunofluorescence staining, Evans blue staining, and Western blotting. The results indicated that EC-Exo inhibited intimal hyperplasia in the carotid artery after balloon injury, promoted re-endothelialization, and reduced vascular inflammation and ROS-NLRP3-mediated cell pyroptosis. Thus, EC-Exo can inhibit neointimal hyperplasia after carotid artery injury in rats presumably by inhibiting the ROS-NLRP3 inflammasome and phenotypic transformation of vascular smooth muscle cells.