{Reference Type}: Case Reports {Title}: A Case of Idiopathic First Bite Syndrome, Possibly Linked to Type I Diabetes Mellitus. {Author}: Stavridopoulos MT;Nikitopoulos SN;Oikonomou AA;Tsiouma GK; {Journal}: Cureus {Volume}: 15 {Issue}: 3 {Year}: 2023 Mar 暂无{DOI}: 10.7759/cureus.36710 {Abstract}: We present a rare case of a 34-year-old male with poorly regulated type I diabetes and three-month history of excruciating pain in the right condylar process of the mandible, occurring only during the first bite of each meal. The patient had no history of surgery or trauma in the head and neck region. Clinical and imaging examination revealed no tumor or pathology deriving from the dentures, the temporomandibular joint (TMJ), or the salivary glands. Idiopathic first bite syndrome (FBS) was suspected and treated with pregabalin and glycemic control. This case highlights how a detailed pain history and clinical examination can lead to a rare diagnosis and indicates the potential involvement of diabetic neuropathy in idiopathic FBS, as well as the importance of glycemic regulation in treatment.