{Reference Type}: Observational Study
{Title}: Estimated sdLDL-C for predicting high-risk coronary plaque features in psoriasis: a prospective observational study.
{Author}: Sorokin AV;Patel N;Li H;Hong CG;Sampson M;O'Hagan R;Florida EM;Teague HL;Playford MP;Chen MY;Mehta NN;Remaley AT;
{Journal}: Lipids Health Dis
{Volume}: 22
{Issue}: 1
{Year}: 2023 Apr 27
{Factor}: 4.315
{DOI}: 10.1186/s12944-023-01819-x
{Abstract}: <B>BACKGROUND: </B>Psoriasis (PSO) is a skin disorder with systemic inflammation and high coronary artery disease risk. A distinct lipid phenotype occurs in psoriasis, which is characterized by high plasma triglycerides (TGs) with typically normal or even low LDL-C. The extent to which cholesterol on LDL subfractions, such as small dense LDL-C (sdLDL-C), are associated with vulnerable coronary plaque characteristics in PSO remains elusive.<BR><B>METHODS: </B>A recently developed equation for estimating sdLDL-C from the standard lipid panel was utilized in a PSO cohort (n = 200) with 4-year follow-up of 75 subjects. Coronary plaque burden was assessed by quantitative coronary computed tomography angiography (CCTA). Multivariate regression analyses were used for establishing associations and prognostic value of estimated sdLDL-C.<BR><B>RESULTS: </B>Estimated sdLDL-C was positively associated with non-calcified burden (NCB) and fibro-fatty burden (FFB), which remained significant after multivariate adjustment for NCB (β = 0.37; P = 0.050) and LDL-C adjustment for FFB (β = 0.29; P < 0.0001). Of note, total LDL-C calculated by the Friedewald equation was not able to capture these associations in the study cohort. Moreover, in the regression modelling estimated sdLDL-C was significantly predicting necrotic burden progression over 4 years follow-up (P = 0.015), whereas LDL-C did not. Finally, small LDL particles (S-LDLP) and small HDL particles (S-HDLP), along with large and medium TG-rich lipoproteins (TRLPs) had the most significant positive correlation with estimated sdLDL-C.<BR><B>CONCLUSIONS: </B>Estimated sdLDL-C has a stronger association than LDL-C with high-risk features of coronary atherosclerotic plaques in psoriasis patients.<BR><B>BACKGROUND: </B>URL: https://www.<BR><B>RESULTS: </B>gov . Unique identifiers: NCT01778569.