{Reference Type}: Journal Article
{Title}: Exploring the role of CD151 in the tumor immune microenvironment: Therapeutic and clinical perspectives.
{Author}: Malla R;Marni R;Chakraborty A;
{Journal}: Biochim Biophys Acta Rev Cancer
{Volume}: 1878
{Issue}: 3
{Year}: 2023 05 23
{Factor}: 11.414
{DOI}: 10.1016/j.bbcan.2023.188898
{Abstract}: CD151 is a transmembrane protein implicated in tumor progression and has been shown to regulate various cellular and molecular mechanisms contributing to malignancy. More recently, the role of CD151 in the tumor immune microenvironment (TIME) has gained attention as a potential target for cancer therapy. This review aims to explore the role of CD151 in the TIME, focusing on the therapeutic and clinical perspectives. The role of CD151 in regulating the interactions between tumor cells and the immune system will be discussed, along with the current understanding of the molecular mechanisms underlying these interactions. The current state of the development of CD151-targeted therapies and the potential clinical applications of these therapies will also be reviewed. This review provides an overview of the current knowledge on the role of CD151 in the TIME and highlights the potential of CD151 as a therapeutic target for cancer treatment.