{Reference Type}: Case Reports
{Title}: A false positive serology test of SARS‑CoV‑2 in a patient with Waldenström's macroglobulinemia: A case report.
{Author}: Lu NN;Liang LZ;Yan XY;Song BY;Zhang YQ;Shu HR;Xu LL;
{Journal}: Exp Ther Med
{Volume}: 25
{Issue}: 5
{Year}: 2023 May
{Factor}: 2.751
{DOI}: 10.3892/etm.2023.11899
{Abstract}: The serology test of SARS-CoV-2 is one of the critical assays to make a diagnosis of SARS-CoV-2 infection. The gold immunochromatography assay (GICA) is a common measure to test SARS-CoV-2 specific IgG and IgM. The sensitivity and specificity of the assay are ~>80%. It has been reported that the result of GICA could be compromised in various situations, such as auto-immune diseases, Kawasaki disease, pregnancy or other conditions. However, following the European Hematology Association's consensus statement on the management of Waldenström's Macroglobulinemia (WM) patients, serological tests for SARS-CoV-2 specific IgM should not be affected by the total IgM or paraprotein levels. The present study reports a patient with duplicate positive serology tests of SARS-CoV-2 which is hypothesized to be due to monoclonal IgM caused by WM.