{Reference Type}: Journal Article
{Title}: Spiroligomer-Based Macrocycles for Atomically Precise Membranes.
{Author}: Xie Y;Luo D;Wiener JA;Koval AB;Pfeiffer CT;Schafmeister CE;
{Journal}: Angew Chem Int Ed Engl
{Volume}: 62
{Issue}: 27
{Year}: 2023 Jul 3
{Factor}: 16.823
{DOI}: 10.1002/anie.202302809
{Abstract}: Here, we report a new class of peptidomimetic macrocycles with well-defined three-dimensional structures and low conformational flexibility. They are assembled from fused-ring spiro-ladder oligomers (spiroligomers) by modular solid-phase synthesis. Two-dimensional nuclear magnetic resonance confirms their shape persistency. Triangular macrocycles of tunable sizes assemble into membranes with atomically precise pores, which exhibit size and shape-dependent molecular sieving towards a series of structurally similar compounds. The exceptional structural diversity and stability of spiroligomer-based macrocycles will be explored for more applications.