{Reference Type}: Case Reports
{Title}: Mirtazapine-induced neutropenic sepsis in an older person: a case report.
{Author}: Maidwell-Smith A;Kirk C;
{Journal}: J Med Case Rep
{Volume}: 17
{Issue}: 1
{Year}: Apr 2023 14
暂无{DOI}: 10.1186/s13256-023-03881-6
{Abstract}: <B>BACKGROUND: </B>Mirtazapine is a frequently prescribed psychotropic drug for depression in older age. It is considered safe and has a side-effect profile uniquely favorable to an older person affected by reduced appetite, difficulty maintaining body weight, or insomnia. However, it is largely unknown that mirtazapine can cause a dangerous decline in neutrophil count.<BR><B>METHODS: </B>We present a case of mirtazapine-induced severe neutropenia in a 91-year-old white British woman requiring drug withdrawal and granulocyte-colony stimulating factor administration.<BR><B>CONCLUSIONS: </B>This case is of significance because mirtazapine is regarded as a safe, and often preferable, antidepressant in older age. However, this case demonstrates a rare, life-threatening side effect of mirtazapine and calls for greater pharmacovigilance when prescribing it. There is no previous report of mirtazapine-induced neutropenia requiring drug withdrawal and granulocyte-colony stimulating factor administration in an older person.