{Reference Type}: Journal Article {Title}: Red porgy's (Pagrus pagrus) cellular physiology and antioxidant defense in response to seasonality. {Author}: Makri V;Feidantsis K;Porlou D;Ntokou A;Georgoulis I;Giantsis IA;Anestis A;Michaelidis B; {Journal}: J Therm Biol {Volume}: 113 {Issue}: 0 {Year}: Apr 2023 {Factor}: 3.189 {DOI}: 10.1016/j.jtherbio.2023.103527 {Abstract}: Physiological stress patterns of marine organisms in their natural habitats are considerably complex in space and time. These patterns can eventually contribute in the shaping of fish' thermal limits under natural conditions. In the view of the knowledge gap regarding red porgy's thermal physiology, in combination with the characterization of the Mediterranean Sea as a climate change ''hotspot'', the aim of the present study was to investigate this species biochemical responses to constantly changing field conditions. To achieve this goal, Heat Shock Response (HSR), MAPKs pathway, autophagy, apoptosis, lipid peroxidation and antioxidant defense were estimated and exhibited a seasonal pattern. In general, all the examined biochemical indicators expressed high levels parallel to the increasing seawater temperature in spring, although several bio-indicators have shown increased levels when fish were cold-acclimatized. Similar to other sparids, the observed patterns of physiological responses in red porgy may support the concept of eurythermy.