{Reference Type}: Journal Article {Title}: Shockwave Therapy in Veterinary Rehabilitation. {Author}: Medina C; {Journal}: Vet Clin North Am Small Anim Pract {Volume}: 53 {Issue}: 4 {Year}: Jul 2023 22 {Factor}: 2.148 {DOI}: 10.1016/j.cvsm.2023.02.009 {Abstract}: Extracorporeal shockwave therapy (ESWT) is a noninvasive treatment that involves the transcutaneous delivery of high-energy sound waves into tissue creating therapeutic effects. Shockwaves are nonlinear, high-pressure, high-velocity acoustic waves characterized by low tensile amplitude, short rise time to peak pressure, and a short duration (less than 10 milliseconds). ESWT has been shown to increase the expression of cytokines and growth factors leading to decreased inflammation, neovascularization, and cellular proliferation; activation of osteogenesis by osteoblast differentiation and then by increased proliferation; inhibition of cartilage degeneration and rebuilding of subchondral bone; and increased serotonin in the dorsal horn and descending inhibition of pain signals. Musculoskeletal conditions that can benefit from ESWT include osteoarthritis, tendinopathies, fracture/bone healing, and wound healing.