{Reference Type}: Journal Article
{Title}: The assessment of cortical hemodynamic responses induced by tubuloglomerular feedback using in vivo imaging.
{Author}: Lee B;Postnov DD;Sørensen CM;Sosnovtseva O;
{Journal}: Physiol Rep
{Volume}: 11
{Issue}: 6
{Year}: 03 2023
暂无{DOI}: 10.14814/phy2.15648
{Abstract}: The tubuloglomerular feedback (TGF) mechanism modulates renal hemodynamics and glomerular filtration rate in individual nephrons. Our study aimed to evaluate the TGF-induced vascular responses by inhibiting Na-K-2Cl co-transporters and sodium-glucose co-transporters in rats. We assessed cortical hemodynamics with high-resolution laser speckle contrast imaging, which enabled the evaluation of blood flow in individual microvessels and analysis of their dynamical patterns in the time-frequency domain. We demonstrated that a systemic administration of furosemide abolishes TGF-mediated hemodynamic responses. Furthermore, we showed that the local microcirculatory blood flow decreased, and the TGF-induced hemodynamic oscillations were sustained but weakened after inhibiting sodium-glucose co-transporters in Sprague-Dawley rats.