{Reference Type}: Journal Article
{Title}: Healthy sleep, mental health, genetic susceptibility, and risk of irritable bowel syndrome.
{Author}: Liu M;Ye Z;Wu Q;Yang S;Zhang Y;Zhou C;He P;Zhang Y;Qin X;
{Journal}: J Affect Disord
{Volume}: 331
{Issue}: 0
{Year}: Jun 2023 15
{Factor}: 6.533
{DOI}: 10.1016/j.jad.2023.03.033
{Abstract}: <B>BACKGROUND: </B>We aimed to investigate the prospective association of individual and combined sleep behaviors and mental health (psychological distress and neuroticism) with incident irritable bowel syndrome (IBS).<BR><B>METHODS: </B>A total of 302,839 participants without prior IBS in the UK Biobank were enrolled. A healthy sleep score was created according to five sleep factors and defined the low-risk groups as follows: sleep 7-8 h/day, early chronotype, never/rarely insomnia, no snoring, and no frequent excessive daytime sleepiness. Psychological distress and neuroticism were ascertained using the Patient Health Questionnaire and the Eysenck Personality Questionnaire-Revised Short Form, respectively. The primary outcome was incident IBS, based on self-report or linkage to death register and/or primary care and/or hospital admission data.<BR><B>RESULTS: </B>During a median follow-up of 12.0 years, 5574 participants developed IBS. Overall, low-risk sleep behaviors and a healthy sleep score (per one point increment, HR, 0.81, 95%CI, 0.79-0.83) were associated with a lower risk of incident IBS, 29.4 %-32.4 % of which was mediated by mental health. Psychological distress (per one point increment, HR, 1.16, 95%CI, 1.14-1.17) and neuroticism (HR, 1.11, 95%CI, 1.10-1.12) were positively associated with incident IBS, and healthy sleep scores mediated 8.3 %-9.7 % of the association. Moreover, participants with lowest healthy sleep score/highest mental health score and higher genetic risk of IBS showed the highest risk of incident IBS.<BR><B>CONCLUSIONS: </B>Sleep behaviors and mental health were assessed by self-reported questionnaires.<BR><B>CONCLUSIONS: </B>Healthy sleep scores and low psychological distress/neuroticism were associated with a lower risk of IBS, regardless of genetic predisposition.