{Reference Type}: Journal Article
{Title}: Gestational exposure to continuous light impairs the development of the female reproductive system in adult Wistar rat offspring.
{Author}: Ogo FM;Siervo GEML;Praxedes AM;Vieira HR;da Silva Scarton SR;Bitencourt ATG;Arena AC;Simão ANC;Guerra MT;de Freitas Mathias PC;Fernandes GSA;
{Journal}: Birth Defects Res
{Volume}: 115
{Issue}: 7
{Year}: 04 2023 15
暂无{DOI}: 10.1002/bdr2.2161
{Abstract}: It has been suggested that maternal exposure to constant light during the gestational period could be considered as a chronic stressor, impairing offspring development by interfering in neuroendocrine and behavior responses.<BR>This study aimed to evaluate whether maternal exposure to continuous light during pregnancy affects the adult reproductive system in the female offspring.<BR>Pregnant Wistar rats were allocated into light-dark (LD) group, exposed to light and dark photoperiod during gestation, and the light-light (LL) group, exposed to a photoperiod of constant light during gestation. After birth, pups were maintained under normal light-dark photoperiod until adulthood. At postnatal day 90, blood was collected from the female offspring, to analyze plasma luteinizing hormone (LH) and progesterone levels, and the uterus and ovaries were harvested for morphometric, histological, and oxidative stress evaluations.<BR>Female exposure to continuous light during the intrauterine period resulted in the adult reduction of LH and increased progesterone plasma levels, and uterine injuries a higher number of endometrial glands and reduced levels of antioxidant enzymes, such as glutathione reductase and glutathione S-transferase. In these experimental conditions, gestational continuous light exposure disturbs sex hormone balance and reduces the antioxidant enzymatic activity in the uterus of female offspring in adult life.