{Reference Type}: Journal Article
{Title}: Synthesis of Cationic Biphen[4, 5]arenes as Biofilm Disruptors.
{Author}: Du X;Ma M;Zhang Y;Yu X;Chen L;Zhang H;Meng Z;Jia X;Chen J;Meng Q;Li C;
{Journal}: Angew Chem Int Ed Engl
{Volume}: 62
{Issue}: 21
{Year}: 05 2023 15
{Factor}: 16.823
{DOI}: 10.1002/anie.202301857
{Abstract}: Since bacteria in biofilms are inherently resistant to antibiotics and biofilm-associated infections pose a serious threat to global public health, new therapeutic agents and schemes are urgently needed to meet clinical requirements. Here two quaternary ammonium-functionalized biphen[n]arenes (WBPn, n=4, 5) were designed and synthesized with excellent anti-biofilm potency. Not only could they inhibit the assembly of biofilms, but also eradicate intractable mature biofilms formed by Gram-positive S. aureus and Gram-negative E. coli bacterial strains. Moreover, they could strongly complex a conventional antibiotic, cefazolin sodium (CFZ) with complex stability constants of (7.41±0.29)×104  M-1 for CFZ/WBP4 and (4.98±0.49)×103  M-1 for CFZ/WBP5. Combination of CFZ by WBP4 and WBP5 synergistically enhanced biofilm eradication performance in vitro and statistically improved healing efficacy on E. coli-infected mice models, providing a novel supramolecular strategy for combating biofilm-associated infections.