{Reference Type}: Journal Article
{Title}: Nickel-Catalyzed Regio- and Enantioselective Ring Opening of 3,4-Epoxy Amides and Esters with Aromatic Amines.
{Author}: Liu J;Tang W;Wang C;
{Journal}: Chemistry
{Volume}: 29
{Issue}: 31
{Year}: Jun 2023 2
{Factor}: 5.02
{DOI}: 10.1002/chem.202300704
{Abstract}: Herein we present a nickel-catalyzed regio- and enantioselective ring opening reaction of 3,4-epoxy amides and esters with aromatic amines as nucleophiles. This method features high regiocontrol, diastereospecific SN 2 reaction pathway, broad substrate scope, and mild reaction conditions, furnishing a wide range of γ-amino acid derivatives in a highly enantioselective manner. Notably, the selective nucleophilic attack to the C-4 position of epoxides is controlled by the directing effect of the pendant carbonyl group.