{Reference Type}: Journal Article
{Title}: Mini-review: Gene regulatory network benefits from three-dimensional chromatin conformation and structural biology.
{Author}: Zhu X;Huang Q;Luo J;Kong D;Zhang Y;
{Journal}: Comput Struct Biotechnol J
{Volume}: 21
{Issue}: 0
{Year}: 2023
{Factor}: 6.155
{DOI}: 10.1016/j.csbj.2023.02.028
{Abstract}: Gene regulatory networks are now at the forefront of precision biology, which can help researchers better understand how genes and regulatory elements interact to control cellular gene expression, offering a more promising molecular mechanism in biological research. Interactions between the genes and regulatory elements involve different promoters, enhancers, transcription factors, silencers, insulators, and long-range regulatory elements, which occur at a ∼10 µm nucleus in a spatiotemporal manner. In this way, three-dimensional chromatin conformation and structural biology are critical for interpreting the biological effects and the gene regulatory networks. In the review, we have briefly summarized the latest processes in three-dimensional chromatin conformation, microscopic imaging, and bioinformatics, and we have presented the outlook and future directions for these three aspects.