{Reference Type}: Journal Article
{Title}: Hemi-synthesis of novel chiral benzodiazepine derivatives from Eucalyptus citriodora essential oil: 2D NMR experiments and differential scanning calorimetry study of diastereoisomers.
{Author}: Cherfaoui B;Chebrouk F;Hassaine R;Khalfaoui M;Boukennna L;Hamroun MSE;Abou-Mustapha M;Lazhar G;
{Journal}: Nat Prod Res
{Volume}: 38
{Issue}: 14
{Year}: Jul 2024 8
{Factor}: 2.488
{DOI}: 10.1080/14786419.2023.2185888
{Abstract}: An efficient in situ condensation of citronellal, the main constituent of Eucalyptus citriodora essential oil (51%), with different amine derivatives of 2,3-diaminomaleonitrile and 3-[(2-aminoaryl)amino]dimedone has led to novel chiral benzodiazepine structures. All reactions were precipitated in ethanol and pure products were obtained in good yields (58-75%) without any purification. The synthesized benezodiazepines were characterized by spectroscopic techniques, namely 1H-NMR, 13C-NMR, 2D NMR and FTIR. Differential Scanning Calorimetry (DSC) and HPLC were used to confirm the formation diastereomeric mixtures of benzodiazepine derivatives.