{Reference Type}: Journal Article
{Title}: An insight overview on COVID-19 mRNA vaccines: Advantageous, pharmacology, mechanism of action, and prospective considerations.
{Author}: Mirtaleb MS;Falak R;Heshmatnia J;Bakhshandeh B;Taheri RA;Soleimanjahi H;Zolfaghari Emameh R;
{Journal}: Int Immunopharmacol
{Volume}: 117
{Issue}: 0
{Year}: Apr 2023
{Factor}: 5.714
{DOI}: 10.1016/j.intimp.2023.109934
{Abstract}: The worldwide spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has urged scientists to present some novel vaccine platforms during this pandemic to provide a rather prolonged immunity against this respiratory viral infection. In spite of many campaigns formed against the administration of mRNA-based vaccines, those platforms were the most novel types, which helped us meet the global demand by developing protection against COVID-19 and reducing the development of severe forms of this respiratory viral infection. Some societies are worry about the COVID-19 mRNA vaccine administration and the potential risk of genetic integration of inoculated mRNA into the human genome. Although the efficacy and long-term safety of mRNA vaccines have not yet been fully clarified, obviously their application has switched the mortality and morbidity of the COVID-19 pandemic. This study describes the structural features and technologies used in producing of COVID-19 mRNA-based vaccines as the most influential factor in controlling this pandemic and a successful pattern for planning to produce other kind of genetic vaccines against infections or cancers.