{Reference Type}: Case Reports
{Title}: Advanced Appendiceal Cancer with Systematic Metastasis without Gastrointestinal Symptoms Found by Subcutaneous Tumor.
{Author}: Nakamura S;Ochiai Y;Nishihara Y;Koyanagi A;Miura Y;Kikuchi D;Takazawa Y;Kuroyanagi H;Hoteya S;
{Journal}: Intern Med
{Volume}: 62
{Issue}: 18
{Year}: Sep 2023 15
{Factor}: 1.282
{DOI}: 10.2169/internalmedicine.0597-22
{Abstract}: An 86-year-old woman with a subcutaneous nodule in her left axilla visited our hospital. She had no gastrointestinal symptoms, but contrast-enhanced computed tomography revealed a cecal mass and systemic metastasis, including cutaneous, bone, peritoneal dissemination and ascites. Colonoscopy revealed a circumferential, elevated cecal lesion. She underwent right hemicolectomy to prevent colon obstruction. The pathological diagnosis was poorly differentiated adenocarcinoma (por1>tub2>muc) arising from the appendix with a BRAFV600E mutation and microsatellite instability-high. Chemotherapy was administered, and she is currently still alive and undergoing chemotherapy. We describe a rare case of advanced appendiceal cancer without gastrointestinal symptoms diagnosed due to cutaneous metastasis.