{Reference Type}: Review
{Title}: [CRISPR-based molecular diagnostics: a review].
{Author}: Sun W;Huang X;Wang X;
{Journal}: Sheng Wu Gong Cheng Xue Bao
{Volume}: 39
{Issue}: 1
{Year}: Jan 2023 25
暂无{DOI}: 10.13345/j.cjb.220317
{Abstract}: Rapid and accurate detection technologies are crucial for disease prevention and control. In particular, the COVID-19 pandemic has posed a great threat to our society, highlighting the importance of rapid and highly sensitive detection techniques. In recent years, CRISPR/Cas-based gene editing technique has brought revolutionary advances in biotechnology. Due to its fast, accurate, sensitive, and cost-effective characteristics, the CRISPR-based nucleic acid detection technology is revolutionizing molecular diagnosis. CRISPR-based diagnostics has been applied in many fields, such as detection of infectious diseases, genetic diseases, cancer mutation, and food safety. This review summarized the advances in CRISPR-based nucleic acid detection systems and its applications. Perspectives on intelligent diagnostics with CRISPR-based nucleic acid detection and artificial intelligence were also provided.