{Reference Type}: Editorial
{Title}: Pain Science in Practice (Part 5): Central Sensitization II.
{Author}: Hoegh M;
{Journal}: J Orthop Sports Phys Ther
{Volume}: 53
{Issue}: 2
{Year}: 02 2023
{Factor}: 6.276
{DOI}: 10.2519/jospt.2023.11571
{Abstract}: SYNOPSIS: Central sensitization is an umbrella-term for facilitated synaptic plasticity. This editorial explains wind-up, classical central sensitization, and long-term potentiation. Wind-up and LTP are generally considered homosynaptic, while classical central sensitization is classified as heterosynaptic. Wind-up is very short lived and unlikely to play a significant role in chronic musculoskeletal pain, however, both LTP and classical central sensitization could potentially be involved in chronic pain. J Orthop Sports Phys Ther 2023;53(2):55-58. doi:10.2519/jospt.2023.11571.