{Reference Type}: Journal Article
{Title}: Proanthocyanidin oligomers extract from hawthorn mediates cell cycle arrest, apoptosis, and lysosome vacuolation on HCT116 cells.
{Author}: Sun YS;Wang ZW;Gao Z;Zhao W;Thakur K;Zhong Q;Wei ZJ;
{Journal}: Curr Res Food Sci
{Volume}: 5
{Issue}: 0
{Year}: 2022
{Factor}: 6.269
{DOI}: 10.1016/j.crfs.2022.05.009
{Abstract}: In this study, Hawthorn oligomic procyanidins extracts (HPOE) were evaluated for their anticancer activity on colorectal cancer. Our results showed that HPOE arrested HCT116 cells cycle at G2/M phase through P53-Cyclin B pathway and promoted apoptosis partly via mitochondrial (Caspase 9-Caspase 3) and death receptor (Caspase 8-Caspase 3) pathways. Meanwhile, it was found that HPOE aggravated HCT116 cells death through lysosomal vacuolation, which was verified by inhibitor/activator of P53-ILC3 signaling pathway. Taken together, HPOE exerted anticancer effects which lays the foundation for the development of functional foods for clinical colon cancer patients.