{Reference Type}: Journal Article
{Title}: Two-step continuous-flow synthesis of 6-membered cyclic iodonium salts via anodic oxidation.
{Author}: Spils J;Wirth T;Nachtsheim BJ;
{Journal}: Beilstein J Org Chem
{Volume}: 19
{Issue}: 0
{Year}: 2023
{Factor}: 2.544
{DOI}: 10.3762/bjoc.19.2
{Abstract}: We describe a multi-step continuous-flow procedure for the generation of six-membered diaryliodonium salts. The accompanying scalability and atom economy are significant improvements to existing batch methods. Benzyl acetates are submitted to this two-step procedure as highly available and cheap starting materials. An acid-catalyzed Friedel-Crafts alkylation followed by an anodic oxidative cyclization yielded a defined set of cyclic iodonium salts in a highly substrate-dependent yield.