{Reference Type}: Journal Article
{Title}: Mutation of the TP53 Gene in Placental Chorangiomatosis.
{Author}: Luo Y;
{Journal}: Fetal Pediatr Pathol
{Volume}: 42
{Issue}: 3
{Year}: Jun 2023 2
{Factor}: 1.412
{DOI}: 10.1080/15513815.2022.2161330
{Abstract}: Objective: We explored the frequency of TP53 gene mutations in chorangiomas (CA) and chorangiomatosis (CM). Materials and -methods: By Sanger sequencing, we evaluated mutations in exons 4-6 of the TP53 gene in CM and CA regions of placentas. Results: In total, 7/11(63.6%) CAs and 24/26 (92.3%) CMs had TP53 mutations, with a significantly higher frequency in the latter. Mutations in both groups predominately involved exon 4, most commonly at the 119th C. The mutation types at the 119th C were C/G and G/G. Among the patients with exon 4 mutations at the 119th C, C/G mutations, the most common type, were observed more frequently in the CM group (63.16%, 12/19) than in the CA group (14.29%, 1/7), and the difference was significant. Conclusion: It is suggested that both CM and CA are tumors rather than tumor-like lesions. Although they are histologically similar, they have a different TP53 profile.