{Reference Type}: Journal Article
{Title}: Renal Histology in CKD Stages: Match or Mismatch with Glomerular Filtration Rate?
{Author}: Trevisani F;Floris M;Cinque A;Bettiga A;Dell'Antonio G;
{Journal}: Nephron
{Volume}: 147
{Issue}: 5
{Year}: Dec 2023 16
{Factor}: 3.457
{DOI}: 10.1159/000527499
{Abstract}: A reliable assessment of renal function is of paramount importance in several clinical assets in order to tailor a personalized medical approach. CKD classification system, created in 2002 by the National Kidney Foundation-sponsored Kidney Disease Outcomes Quality Initiative and then implemented in the following years by the K-DIGO guidelines, offered clinicians a new strategy to better identify nephrological patients at low or high risk to develop renal insufficiency, in order to avoid the progression to end-stage renal disease. However, the criteria used to create this classification did not consider some important aspects related to renal histology and glomerular filtration rate measurement, resulting in a possible over- or underestimation of the real established renal damage. In this mini-review, we will summarize the most relevant shortcomings in the CKD classifications, which can create misleading diagnosis in daily clinical practice.