{Reference Type}: Journal Article
{Title}: Scleredema diabeticorum.
{Author}: Pereira M;Pinheiro RR;Lencastre A;Bártolo E;
{Journal}: Dermatol Reports
{Volume}: 14
{Issue}: 4
{Year}: Nov 2022 21
暂无{DOI}: 10.4081/dr.2022.9477
{Abstract}: Scleredema of Buschke is a rare connective tissue disease with a poorly understood pathogenesis. Three types of scleredema have been distinguished according to its association with preceding or underlying conditions. Type 1 is usually secondary to a febrile infection, type 2 is mostly associated with paraproteinemia and type 3, usually named scleredema diabeticorum, has a strict association with Diabetes mellitus. A diffuse, non-pitting swelling and induration of the skin define this disease. The skin histology is characterized by a normal or slightly thinned epidermis, and the dermis containing a decreased number of elastic fibers and thick large swollen collagen bundles separated by mucopolysaccharide deposits in the deep reticular dermis. In this report we present a 58-year-old man with scleredema diabeticorum controlled with a topical steroid cream and an optimization of glycemic control. We reviewed clinical, histopathological characteristics and the various possible treatments.