{Reference Type}: Review
{Title}: Toxic Epidermal Necrolysis: A Review of Past and Present Therapeutic Approaches
{Author}: Singh N;Phillips M;
{Journal}: Skin Therapy Lett
{Volume}: 27
{Issue}: 5
{Year}: 09 2022
暂无{Abstract}: Toxic epidermal necrolysis (TEN) is an immune mediated, severe cutaneous adverse drug reaction characterized by epidermal detachment affecting greater than 30% body surface area. The mortality rate of TEN exceeds 20% and is usually caused by infection and respiratory compromise. Withdrawal of the causative drug, supportive care, and adjuvant therapy improve prognosis. Over the past decade, randomized controlled trials and meta-analyses have supported a role for cyclosporine, tumor necrosis factor alpha inhibitors, and combination therapy with intravenous immune globulin and corticosteroids. This review summarizes the medical management of TEN in adult patients.