{Reference Type}: Journal Article
{Title}: Clinical risk factors for vasculo-placental disorders: results from a prospective case-control study nested in HEMOTHEPP French cohort study.
{Author}: de Moreuil C;Pan-Petesch B;Trémouilhac C;Dupré PF;Merviel P;Anouilh F;Bellot C;Müller M;Drugmanne G;Nowak E;Coadic J;Bihan L;Gourhant L;Lemarié C;Robin S;Couturaud F;Moigne EL;
{Journal}: J Gynecol Obstet Hum Reprod
{Volume}: 52
{Issue}: 1
{Year}: Jan 2023
{Factor}: 2.156
{DOI}: 10.1016/j.jogoh.2022.102511
{Abstract}: <B>OBJECTIVE: </B>Determine clinical risk factors for vasculo-placental disorders in singleton pregnancies.<BR><B>METHODS: </B>Prospective case-control study nested in HEMOTHEPP French cohort.<BR><B>METHODS: </B>Women delivered between June, 2015 and January, 2019 in any maternity ward of Finistère.<BR><B>METHODS: </B>Cases were women with vasculo-placental disorders (pre-eclampsia, intrauterine growth restriction (IUGR), placental abruption or stillbirth). Controls were women matched for age at delivery and parity.<BR><B>METHODS: </B>Clinical data were collected by obstetricians or midwives during antenatal care visits and delivery, and recorded by trained research assistants.<BR><B>METHODS: </B>Occurrence of a vasculo-placental disorder.<BR><B>RESULTS: </B>505 women with vasculo-placental disorder (299 pre-eclampsia, 253 IUGR, 44 placental abruptions, 11 stillbirths) and 1515 matched controls were selected out of 20,075 participants. In multivariable analysis, four clinical parameters were associated with pre-eclampsia: obesity (Odd ratio (OR) = 3.11, 95%CI 2.11-4.58), French overseas origin (OR = 4.41, 95%CI 1.87-10.42), previous vasculo-placental disorder (OR = 5.14, 95%CI 2.72-9.70), aspirin during pregnancy (OR = 10.10, 95%CI 1.99-51.08). Three clinical parameters were associated with IUGR: auto-immune/inflammatory disorder (OR = 3.75, 95%CI 1.83-7.68), previous vasculo-placental disorder (OR = 3.63, 95%CI 2.06-6.41), smoking during pregnancy (OR = 2.66, 95%CI 1.91- 3.71). A previous venous thromboembolism (VTE) was associated with IUGR in univariable but not in multivariable analysis (OR = 3.72, 95%CI 0.82-17.00, p = 0.09).<BR><B>CONCLUSIONS: </B>Clinical risk factors differ between IUGR and pre-eclampsia, the later, but not the former, being associated with cardiovascular risk factors.