{Reference Type}: Journal Article
{Title}: Micro RNA-411 Expression Improves Cardiac Phenotype Following Myocardial Infarction in Mice.
{Author}: Nugroho AB;Stafford N;Zi M;Prehar S;Potter R;Kwon D;Kohar YS;Triastuti E;Bui TA;Cartwright EJ;Oceandy D;
{Journal}: JACC Basic Transl Sci
{Volume}: 7
{Issue}: 9
{Year}: Sep 2022
{Factor}: 9.531
{DOI}: 10.1016/j.jacbts.2022.05.008
{Abstract}: Induction of endogenous regenerative capacity has emerged as one promising approach to repair damaged hearts following myocardial infarction (MI). Re-expression of factors that are exclusively expressed during embryonic development may reactivate the ability of adult cardiomyocytes to regenerate. Here, we identified miR-411 as a potent inducer of cardiomyocyte proliferation. Overexpression of miR-411 in the heart significantly increased cardiomyocyte proliferation and survival in a model MI. We found that miR-411 enhances the activity of YAP, the main downstream effector of the Hippo pathway, in cardiomyocytes. In conclusion, miR-411 induces cardiomyocyte regeneration and improves cardiac function post-MI likely by modulating the Hippo/YAP pathway.