{Reference Type}: Systematic Review
{Title}: The effect of SSRIs on Semen quality: A systematic review and meta-analysis.
{Author}: Xu J;He K;Zhou Y;Zhao L;Lin Y;Huang Z;Xie N;Yue J;Tang Y;Xu J;He K;Zhou Y;Zhao L;Lin Y;Huang Z;Xie N;Yue J;Tang Y;
{Journal}: Front Pharmacol
{Volume}: 13
{Issue}: 0
{Year}: 2022
{Factor}: 5.988
{DOI}: 10.3389/fphar.2022.911489
{Abstract}: Selective serotonin reuptake inhibitors (SSRIs) are widely used for a variety of diseases, and their impact on semen quality is unclear. We performed a systematic search in PubMed and Embase, and after a strict screening, we included 4 studies with a total of 222 male participants. In result, SSRIs reduced normal sperm morphology (95% CI [-16.29, -3.77], p = 0.002), sperm concentration (95%CI [-43.88, -4.18], p = 0.02), sperm motility (95%CI [-23.46, -0.47], p = 0.04) and sperm DNA fragmentation index (DFI) (95% CI [6.66,21.93], p = 0.0002), without a statistically significant effect on semen volume (95%CI [-0.75,0.65], p = 0.89). Moreover, the impact on both sperm morphology and sperm concentration were observed within the 3-month period of SSRIs use. In general, our meta-analysis showed that SSRIs have a negative effect on semen quality. More larger, randomized, well-controlled clinical studies should be conducted to support our conclusion.