{Reference Type}: Journal Article
{Title}: It's the water! The open and shut case of drug-induced integrin activation.
{Author}: Coller BS;
{Journal}: Cell
{Volume}: 185
{Issue}: 19
{Year}: 09 2022 15
{Factor}: 66.85
{DOI}: 10.1016/j.cell.2022.08.015
{Abstract}: Integrin receptors are established drug targets, but many of the drugs that have been developed act as partial agonists, inducing the receptor into a high-affinity, ligand-binding state. Lin et al. discovered a general mechanism to circumvent this problem-stabilizing a key water molecule that prevents receptor activation. Their findings are likely to impact future therapeutic development.