{Reference Type}: Journal Article
{Title}: Role of muscle biopsy in diagnosis of extraocular muscles enlargement.
{Author}: Abouelatta MM;Shalaby OE;Awara AM;Kikkawa DO;Liu CY;Eldesouky MA;
{Journal}: Int Ophthalmol
{Volume}: 43
{Issue}: 3
{Year}: Mar 2023
{Factor}: 2.029
{DOI}: 10.1007/s10792-022-02470-8
{Abstract}: <B>OBJECTIVE: </B>To study the role of muscle biopsy in patients with enlarged extraocular muscles.<BR><B>METHODS: </B>A retrospective review of 31 patients who underwent biopsy for extraocular muscle enlargement. Characteristics, including signs, symptoms, imaging findings, and histopathological assessment were examined.<BR><B>RESULTS: </B>Chronic inflammatory disorders represented the most common cause of the muscle enlargement followed by malignancy/metastasis. Multiple muscle involvement was more consistent with benign diseases, whereas single muscle involvement was more consistent with malignant causes. Positive predictive value of muscle biopsy was 0.52 for determining a specific cause of the muscle enlargement.<BR><B>CONCLUSIONS: </B>Muscle biopsy is the standard for diagnosis in patients with extraocular muscle enlargement. This diagnostic test should be performed in every case of non-resolving muscle enlargement, with a specific diagnosis being made in over half of cases.