{Reference Type}: Journal Article
{Title}: Combined Hepatocellular-Cholangiocarcinoma: An Update on Pathology and Diagnostic Approach.
{Author}: Choi JH;Ro JY;Choi JH;Ro JY;Choi JH;Ro JY;
{Journal}: Biomedicines
{Volume}: 10
{Issue}: 8
{Year}: Jul 2022 29
{Factor}: 4.757
{DOI}: 10.3390/biomedicines10081826
{Abstract}: Combined hepatocellular-cholangiocarcinoma (cHCC-CCA) is a rare primary liver carcinoma displaying both hepatocytic and cholangiocytic differentiation within the same tumor. Relative to classic hepatocellular carcinoma (HCC), cHCC-CCA has more aggressive behavior and a poorer prognosis. Though recent advances have improved our understanding of the biology underlying cHCC-CCAs, they remain diagnostically challenging for pathologists because of their morphologic and phenotypic diversity. Accurate diagnosis of cHCC-CCA is important for patient management and prognostication. Herein, we review recent updates on cHCC-CCA, focusing on tumor classification, pathology, and diagnostic approach.