{Reference Type}: Editorial {Title}: A Plea for Economically Sustainable Evidence-based Guidelines. {Author}: Martini A;Mottet N;Montorsi F;Necchi A;Ribal MJ;Malavaud B; {Journal}: Eur Urol {Volume}: 82 {Issue}: 5 {Year}: 11 2022 {Factor}: 24.267 {DOI}: 10.1016/j.eururo.2022.08.001 {Abstract}: The rising costs of cancer care with the introduction of new agents are a challenge. The impact of these costs differs among countries. We compare costs for metastatic prostate cancer, with prices normalized to international dollars, as an example that highlights the need for cost-effectiveness analyses in trials and treatment guidelines.